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Home Antibody All anti-MAP2 antibodies

Anti-MAP2 PHOSPHO Antibody EPR2361

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307036
  • Rabbit monoclonal antibody against MAP2 Phospho (pS136) (clone EPR2361 ) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues surrounding Serine 136 of human MAP2 was used as an immunogen.
Clone NameEPR2361 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens microtubule-associated protein 2 (MAP2), transcript variant 3
Alternative NameMAP2A, MAP2B, MAP2C;DKFZp686I2148; MAP2A; MAP2B; MAP2C; OTTHUMP00000163916; microtubule-associated protein 2
Database LinkNP_114034
FunctionMicrotubule-associated protein-2 (MAP-2) is a family of heat-stable, phosphoproteins expressed predominantly in the cell body and dendrites of neurons. Three major MAP-2 isoforms, (MAP2a, and MAP2b (280 kDa), MAP2c (75 kDa)) are differentially expressed during the development of the nervous system and have an important role in microtubule dynamics (1). MAP2 is proposed to play important roles in the outgrowth of neuronal processes, synaptic plasticity and neuronal cell death. MAP2 may perform many functions including the nucleation and stabilization of microtubules, the regulation of organelle transport within axons and dendrites, as well as the anchorage of regulatory proteins such as protein kinases which may be important for signal transduction (2). MAP2 is an important cytoskeleton protein whose phosphorylation in response to extracellular signal is involved in the regulation of neurite outgrowth and neuronal plasticity. Findings suggest that epinephrine induces phosphorylation of MAP2c at Serine 136 through an alpha 2-adrenoceptor mediated, ERK/PKC-dependent signaling pathway, which may contribute to the stabilization of neuritis (3).
Related Pathway

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WB Image
Western blot - MAP2 (phospho S136) antibody [EPR2361]; All lanes : Anti-MAP2 (phospho S136) antibody [EPR2361] at 1/1000 dilution.Lane 1 : Untreated fetal brain lysates.Lane 2 : Fetal brain lysates treated with Alkaline Phosphatase.Lane 3 : Mouse brain lysates.Lysates/proteins at 10 µg per lane.Secondary.HRP/AP polymerized antibody.Predicted band size : 200 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MAP2 (phospho S136) antibody [EPR2361]; TA307036, at a 1/100 dilution, staining MAP2 in paraffin embedded Human brain tissue by Immunohistochemical analysis.

 

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