Microtubule-associated protein-2 (MAP-2) is a family of heat-stable, phosphoproteins expressed predominantly in the cell body and dendrites of neurons. Three major MAP-2 isoforms, (MAP2a, and MAP2b (280 kDa), MAP2c (75 kDa)) are differentially expressed during the development of the nervous system and have an important role in microtubule dynamics (1). MAP2 is proposed to play important roles in the outgrowth of neuronal processes, synaptic plasticity and neuronal cell death. MAP2 may perform many functions including the nucleation and stabilization of microtubules, the regulation of organelle transport within axons and dendrites, as well as the anchorage of regulatory proteins such as protein kinases which may be important for signal transduction (2). MAP2 is an important cytoskeleton protein whose phosphorylation in response to extracellular signal is involved in the regulation of neurite outgrowth and neuronal plasticity. Findings suggest that epinephrine induces phosphorylation of MAP2c at Serine 136 through an alpha 2-adrenoceptor mediated, ERK/PKC-dependent signaling pathway, which may contribute to the stabilization of neuritis (3).
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