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Home Antibody All anti-MAP1LC3A antibodies

Anti-MAP1LC3A Antibody EP1983Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300953
  • Rabbit Monoclonal Antibody against MAP1LC3A (Clone EP1983Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC403169) , 20ug
100uL $325 3-7 Days
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WB(1)
IHC(1)
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Also for MAP1LC3A (NM_032514)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human MAPILC3A was used as an immunogen.
Clone NameEP1983Y IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:5000 - 1:10000; IP: 1:40; FC: 1:40; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens microtubule-associated protein 1 light chain 3 alpha (MAP1LC3A), transcript variant 1
Alternative NameATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3
Database LinkNP_115903
FunctionMicrotubule-associated MAPILC3A constitute nearly half of the mass of all the microtubule associated proteins that copurify with brain microtubules. MAPILC3A is composed of a heavy chain and multiple light-chain subunits. Amino acid sequencing of a 120 kd microtubule-binding and light chain-binding fragment of the heavy chain reveals that light chain 1 binds near the heavy chain N-terminus. These data indicate that the heavy chain and light chain 1 are produced by proteolytic processing of a MAP1B polyprotein and form a complex microtubule-binding domain (1). There are three human orthologs of the rat Map1LC3, named MAP1LC3A, MAP1LC3B, and MAP1LC3C. The three isoforms of human MAP1LC3 exhibit distinct expression patterns in different human tissues and also differ in their post-translation modifications. MAP1LC3A and MAP1LC3C are produced by the proteolytic cleavage after the conserved C-terminal Gly residue; MAP1LC3B does not undergo C-terminal cleavage and exists in a single modified form (2).
Related Pathway
Senescence and Autophagy

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WB Image
Western blot - MAP1LC3A antibody [EP1983Y]; Anti-MAP1LC3A antibody [EP1983Y] at 1/10000 dilution + Hela cell lysate at 10 µg.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 14 kDa.Observed band size : 16 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - MAP1LC3A antibody [EP1983Y]; Immunohistochemical staining of MAP1LC3A in paraffin embedded human breast carcinoma using TA300953 at a 1/100 dilution.

 

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