Home Antibody All anti-M6PRBP1 antibodies
Also for M6PRBP1 (NM_001164189)
|TIP47 antibody was raised against a 14 amino acid peptide from near the amino terminus of human TIP47.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens perilipin 3 (PLIN3), transcript variant 2|
|M6PRBP1; PP17; TIP47|
|Tail-interacting protein (TIP47) is a cytosolic protein essential for the transport of mannose-6-phosphate receptors (MPRs) from endosomes to the trans-Golgi compartments in cells. TIP47 is recruited from the cytoplasm to the late endosomal surface by the Ras-associated protein Rab9 GTPase, enabling it to bind more efficiently to MPR cytoplasmic domains. Recently, it was shown that TIP47 regulates the expression of Rab9, as expression of siRNA to TIP47 in transfected cells dramatically decreased the half-life of the Rab9 protein in addition to stabilizing the subcellular localization of Rab9. At least two isoforms of TIP47 are known to exist.|
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Western blot analysis of TIP47 in EL4 cell lysate with TIP47 antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry of TIP47 in rat liver tissue with TIP47 antibody at 2 ug/ml.