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Home Antibody All anti-Lamp2 antibodies

Anti-Lamp2 Antibody GL2A7

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326492
  • Rat Monoclonal Anti-LAMP2 Antibody
100µg $325 3-7 Days
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IF(1)

OriGene Data

ImmunogenPurified preparation of mouse liver lysosomal membranes
Clone NameGL2A7 IsotypeIgG1
Species ReactivityMouse, Rabbit Concentration1mg/mL
Guaranteed Application *IF Suggested DilutionsICC: 1:500- 1:1000
BufferPBS pH7.4, 50% glycerol, 0.09% sodium azide
Purification Protein G Purified
Note Recommended for use in ICC. The antibody will label the presumptive lysosomes and late endosomes in cells that have been permeabilized with saponin.

Reference Data

Target NameMus musculus lysosomal-associated membrane protein 2 (Lamp2), transcript variant 1
Alternative NameCD107b; Lamp-2; Lamp-2a; Lamp-2b; Lamp-2c; Mac3
Database LinkNP_001017959
FunctionLysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology . They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane .LAMP2 has also been detected at the plasma membrane of cells, as well as in cells that secrete lysosomal hydrolases. A study in the developmental expresses patterns of membrane LAMP2 transcripts indicate a possible involvement of this protein in cell-cell or cell-extracellular matrix interaction, and appear to reflect tissue and cell type specific roles of lysosomes during morphogenesis . Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxyl-terminal tyrosine based motif (YXXI) . This stimulation has also been shown to have an associated release of histamine, leukotriene C 9$) and prostaglandin D 9@), which shows that LAMP1 and LAMP2 are activation markers for normal mast cells . They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation . LAMP2 has also been shown to be critical for autophagy, in conversion of early autophagic vacuoles to vacuoles which rapidly degrade their content .
Related Pathway

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IF Image
Distribution of lysosomes in CEC was determined using Anti-LAMP2, shown with IF. Courtesy of Dr. Kay, Doheny Eye Institute, USA.

 

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