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Home Antibody All anti-LYVE1 antibodies

Anti-LYVE1 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA301773 Rabbit Polyclonal Antibody against LYVE1 100ul $325 3-7 Days
LC402008 LYVE1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide made to a C-terminal portion of the human LYVE-1 protein sequence (between residues 250-322).
Clone Name IsotypeIgG
Species Reactivityhuman, mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1: 1000
BufferTris-glycine, 150 mM NaCl and .05% Sodium azide
Purification Affinity purified

Reference Data

Target NameHomo sapiens lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1)
Alternative NameCRSBP-1; HAR; LYVE-1; XLKD1
Database LinkNP_006682
Entrez Gene 10894 Human
Entrez Gene 114332 Mouse
FunctionThe lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. Recently a number of interesting molecules have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, and podoplanin. LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module, the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
Related PathwayTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Detection of LYVE-1 in recombinant human protein, ECL detection overnight
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Western Blot: LYVE1 Antibody - Detection of LYVE-1 in mouse spleen lysate. ECL detection overnight.
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