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Anti-LYPLA1 Antibody EPR3667
Also for LYPLA1 (NM_006330)
|A synthetic peptide corresponding to residues in human Acyl protein thioesterase 1 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||ICC: 1:500 - 1000, IHC: 1:100 - 250, IP: 1:10, WB: 1:5,000 - 20,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens lysophospholipase I (LYPLA1), transcript variant 1|
|APT-1; APT1; hAPT1; LPL-I; LPL1|
Entrez Gene 10434 Human
Entrez Gene 18777 Mouse
Entrez Gene 25514 Rat
|Acyl-protein thioesterase 1 (APT1, Lysophospholipase 1) is a member of a family of critical enzymes, lysophospholipases, that act on biological membranes to regulate the multifunctional lysophospholipids (1). APT1 hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (2). The role of APT1 in regulating lysophospholipids is important because increased levels of lysophospholipids are detected in a variety of diseases, including atherosclerosis and hyperlipidemia (1). Regulated expression of acyl-protein thioesterase by PKC has been suggested to have important implications for signal transduction processes (3). |
| Glycerophospholipid metabolism|
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Western blot - Lysophospholipase 1 antibody [EPR3667]; All lanes : Anti-Lysophospholipase 1 antibody [EPR3667] at 1/5000 dilution.Lane 1 : Fetal liver lysate.Lane 2 : Fetal heart lysate.Lane 3 : Human spleen lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit IgG at 1/1000 dilution.Predicted band size : 25 kDa.
Western blot - Lysophospholipase 1 antibody [EPR3667]; All lanes : Anti-Lysophospholipase 1 antibody [EPR3667] at 1/5000 dilution.Lane 1 : Mouse heart lysate.Lane 2 : Mouse kidney lysate.Lane 3 : Mouse spleen lysate.Lane 4 : Rat kidney lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit IgG at 1/1000 dilution.Predicted band size : 25 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Lysophospholipase 1 antibody [EPR3667]; TA307163, at a 1/100 dilution, staining Lysophospholipase 1 in paraffin-embedded Human brain tissue by Immunohistochemistry.