Home Antibody All anti-LY96 antibodies
Also for LY96 (NM_015364)
|MD-2 antibody was raised against a peptide corresponding to amino acids near the middle region of human MD-2.|
|Human, Mouse, Rat
||WB: 0.5 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified
|Homo sapiens lymphocyte antigen 96 (LY96), transcript variant 1|
|ESOP-1; ly-96; MD-2; MD2|
|MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS (5,6). The specificity of this response is determined by the species of MD-2; e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4 (7).|
Toll-like receptor signaling pathway
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Western blot analysis of MD-2 in mouse spleen cell lysate with MD-2 antibody at 1 ug/ml.
Immunohistochemical staining of rat spleen cells using MD-2 antibody at 2 ug/ml.