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Home Antibody All anti-LTA4H antibodies

Anti-LTA4H Antibody EPR5712

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310667
  • Rabbit Monoclonal antibody against LTA4H
  • FREE positive control: HEK293T cell transient overexpression lysate (LC424467) , 20ug
100ul $325 3-7 Days
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WB(1)
IHC(1)
Assay(1)
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Also for LTA4H (NM_000895)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human LTA4H was used as an immunogen.
Clone NameEPR5712 IsotypeTissue culture supernatant
Species ReactivityHuman, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500; FC: 1:100 - 1:500
BufferDoes not react with Mouse. Is unsuitable for ICC.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC.

Reference Data

Target NameHomo sapiens leukotriene A4 hydrolase (LTA4H), transcript variant 1
Alternative Nameleukotriene A4 hydrolase
Database LinkNP_000886
FunctionThe leukotrienes are a group of proinflammatory lipid mediators that have been implicated in the pathogenesis and progression of atherosclerosis. LTA4H, or leukotriene A4 hydrolase, is a bifunctional enzyme with aminopeptidase and epoxide hydrolase activities that utilize a single zinc active site (1). The aminopeptidase activity of LTA4H, but not epoxide hydrolase activity, highly depends on certain monovalent anions, especially chloride and thiocyanate ions (2). As a member of the peptidase M1 family, LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4), which acts as a chemoattractant and an activator of inflammatory responses mediated by binding to G-protein-coupled receptors BLT1 and BLT2 (1, 3).
Related Pathway

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WB Image
Western blot - Leukotriene A4 hydrolase antibody [EPR5712]; All lanes : Anti-Leukotriene A4 hydrolase antibody [EPR5712] at 1/10000 dilution.Lane 1 : HeLa cell lysate .Lane 2 : 293T cell lysate.Lane 3 : T47D cell lysate.Lane 4 : A549 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 69 kDa.
Assay Image
Other-Anti-Leukotriene A4 hydrolase antibody [EPR5712](TA310667); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Leukotriene A4 hydrolase antibody [EPR5712]; Immunohistochemical analysis of Leukotriene A4 hydrolase in paraffin-embedded Human breast carcinoma tissue using TA310667 at 1/250 dilution.

 

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