Home Antibody All anti-LRP6 antibodies
Also for LRP6 (NM_002336)
|This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1560 amino acids from the C-terminal region of human LRP6.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000, IHC: 1:10~50
|Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.|
|This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
|Homo sapiens low density lipoprotein receptor-related protein 6 (LRP6)|
Entrez Gene 4040 Human
|LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.|
|TransmembraneDruggable Genome Wnt signaling pathway|
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Western blot analysis of LRP6 (arrow) using rabbit polyclonal LRP6 Antibody (C-term T1546) (Cat# TA302210). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the LRP6 gene (Lane 2) (Origene Technologies).
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with LRP6 Antibody (C-term T1546)(Cat.#TA302210), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.