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Home Antibody All anti-LRP2 antibodies

Anti-LRP2 Antibody EPR5875

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SKU Description Amount Price Availability*  
TA310664 Rabbit Monoclonal antibody against LRP2 100ul $325 In Stock
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WB(2)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the cytoplasmic domain of human LRP2 was used as an immunogen.
Clone NameEPR5875 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 522 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens low density lipoprotein receptor-related protein 2 (LRP2)
Alternative NameDBS; GP330
Database LinkNP_004516
Entrez Gene 4036 Human
Entrez Gene 14725 Mouse
Entrez Gene 29216 Rat
FunctionLRP2, low density lipoprotein-related protein 2 or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. LRP2 is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. It also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog, while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in LRP2 cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR) (1).
Related PathwayTransmembraneDruggable Genome Hedgehog signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-Lrp2 / Megalin antibody [EPR5875]; All lanes : Anti-Lrp2 / Megalin antibody [EPR5875] at 1/1000 dilution.Lane 1 : Human thyroid lysate.Lane 2 : 293T lysate.Lane 3 : Human adrenal gland lysate.Lane 4 : Caco 2 lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 522 kDa.
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Western blot - Anti-Lrp2 / Megalin antibody [EPR5875]; .Predicted band size : 522 kDa.
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