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Home Antibody All anti-LMNA antibodies

Anti-LMNA Antibody

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA308920 Rabbit Polyclonal antibody to Lamin A/C (lamin A/C) 100ul $325 3-7 Days
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WB(2)
IHC(3)
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OriGene Data

ImmunogenRecombinant fragment contain a sequence corresponding to a region within amino acids 59 and 572 of Lamin A/C
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Chimpanzee) Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsIHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 65kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Chimpanzee (100%)

Reference Data

Target NameHomo sapiens lamin A/C (LMNA), transcript variant 3
Alternative NameCDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
Database LinkNP_733822
Entrez Gene 4000 Human
FunctionThe nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq]
Related PathwayDruggable Genome Hypertrophic cardiomyopathy (HCM)Arrhythmogenic right ventricular cardiomyopathy (ARVC)Dilated cardiomyopathy

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Lamin A/C antibody detects LMNA protein by Western blot analysis. A. 30 ug NIH-3T3 whole cell lysate/extract. 7.5 % SDS-PAGE. Lamin A/C antibody (TA308920) dilution: 1:1000
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WB Image
Sample (20 ug ). A: HeLa Nucleus. 10% SDS PAGE. TA308920 diluted at 1:3000.
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IHC Image
Immunohistochemical analysis of paraffin-embedded H441 Xenograft, using Lamin A/C(TA308920) antibody at 1:100 dilution.
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IHC Image
Lamin A/C antibody detects Lamin A/C protein at nuclear envelope on mouse fore brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse fore brain. Lamin A/C antibody (TA308920) dilution: 1:500.
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IHC Image
Lamin A/C antibody detects Lamin A/C protein at nuclear envelope on mouse prostate by immunohistochemical analysis. Sample: Paraffin-embedded mouse prostate. Lamin A/C antibody (TA308920) dilution: 1:500.
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