Home Antibody All anti-LMNA antibodies
Also for LMNA (NM_170708)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 59 and 259 of Lamin A/C|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens lamin A/C (LMNA), transcript variant 3|
|CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;|
Entrez Gene 4000 Human
|The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq]|
|Druggable Genome Hypertrophic cardiomyopathy (HCM)Arrhythmogenic right ventricular cardiomyopathy (ARVC)Dilated cardiomyopathy|
* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
A: HeLa Nucleus (anti-LMNA antibody diluted at 1:3000
Immunohistochemical analysis of paraffin-embedded H441 Xenograft, using Lamin A/C(anti-LMNA antibody) antibody at 1:100 dilution.