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Home Antibody All anti-LMNA antibodies

Anti-LMNA Antibody EPR4100

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306999
  • Rabbit monoclonal antibody against Lamin A/C(clone EPR4100)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC406886) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(6)
IF(1)
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Also for LMNA (NM_170707)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Lamin A/C was used as an immunogen.
Clone NameEPR4100 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF: 1:250 - 1:500; WB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500; FC: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens lamin A/C (LMNA), transcript variant 1
Alternative NameCDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
Database LinkNP_733821
FunctionThe nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins makes up the matrix and is highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B (1). By alternate splicing, lamin A/C produces the following three isoforms: isoform A (74 kDa), isoform C (65 kDa), and isoform ADelta10 (70 kDa) (2). Mutations in lamin A/C lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome (1).
Related Pathway
Adipogenesis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Lamin A antibody [EPR4100]; All lanes : Anti-Lamin A + C [EPR4100] antibody at 1/10000 dilution.Lane 1 : HeLa cell lysates .Lane 2 : SH-SY5Y cell lysates .Lysates/proteins at 10 ug per lane.Predicted band size : 74 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Lamin A antibody [EPR4100]; TA306999 at 1/250 dilution staining Lamin A in Human brain by Immunohistochemistry, Paraffin-embedded tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Lamin A antibody [EPR4100]; TA306999 at 1/250 dilution staining Lamin A in Human liver by Immunohistochemistry, Paraffin-embedded tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Lamin A antibody [EPR4100](TA306999); Fluorescent immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using TA306999. Green-Lamin red-PI.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Lamin A antibody [EPR4100](TA306999); Fluorescent immunohistochemical analysis of paraffin-embedded human cervical carcinoma tissue using TA306999. Green-Lamin red-PI.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Lamin A antibody [EPR4100](TA306999); Fluorescent immunohistochemical analysis of paraffin-embedded human urothelial carcinoma tissue using TA306999. Green- Lamin red-PI.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Lamin A antibody [EPR4100](TA306999); Fluorescent immunohistochemical analysis of paraffin-embedded human colonic carcinoma tissue using TA306999. Green- Lamin red-PI.
IF Image
Immunocytochemistry/ Immunofluorescence - Lamin A antibody [EPR4100]; TA306999 at 1/250 dilution staining Lamin A in HeLa cells by Immunofluorescence.

 

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