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Home Antibody All anti-LMNA antibodies

Anti-LMNA Antibody EPR4068

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306998
  • Rabbit monoclonal antibody against Lamin A/C(clone EPR4068)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC406886) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(7)
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Also for LMNA (NM_170707)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Lamin A/C was used as an immunogen.
Clone NameEPR4068 IsotypeIgG
Species ReactivityMouse, Rat, Human, Spermophilus tridecemlineatus ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens lamin A/C (LMNA), transcript variant 1
Alternative NameCDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC;
Database LinkNP_733821
Entrez Gene 4000 Human
Entrez Gene 16905 Mouse
Entrez Gene 60374 Rat
FunctionThe nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome (1).
Related PathwayDruggable Genome Hypertrophic cardiomyopathy (HCM)Arrhythmogenic right ventricular cardiomyopathy (ARVC)Dilated cardiomyopathy

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Lamin A + C [EPR4068] antibody; All lanes : Anti-Lamin A + C [EPR4068] antibody at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : HACAT cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 74 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin A + C [EPR4068] antibody; Immunohistochemical analysis of paraffin-embedded human brain tissue using TA306998 at a dilution of 1/100.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin A + C [EPR4068] antibody; Immunohistochemical analysis of paraffin-embedded human colonic tissue using TA306998 at a diltion of 1/100
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin A + C [EPR4068] antibody; TA306998 showing positive staining in Normal breast tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin A + C [EPR4068] antibody; TA306998 showing positive staining in Normal uterus tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin A + C [EPR4068] antibody; TA306998 showing positive staining in Normal kidney tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin A + C [EPR4068] antibody; TA306998 showing positive staining in Normal tonsil tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin A + C [EPR4068] antibody; TA306998 showing positive staining in Normal stomach tissue.

 

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