Home Antibody All anti-LIPE antibodies
Also for LIPE (NM_005357)
|Lipe antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human lipe.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens lipase, hormone-sensitive (LIPE)|
|AOMS4; HSL; LHS|
Entrez Gene 3991 Human
Entrez Gene 16890 Mouse
Entrez Gene 25330 Rat
|Although initially described as an adipocyte-specific triacylglycerol lipase, lipe (also known as hormone-specific lipase or HSL) is expressed in multiple tissues and cell lines. It plays multiple roles in lipid metabolism, including hormone-stimulated lipolysis in adipose tissue and the hydrolysis of cholesterol esters. Lipe is expressed as a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesterol esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. Recently, it was observed that the lack of lipe in genetically obese leptin-null mice inhibited obesity and adipogenesis, suggesting that lipe plays a major role in adipocyte proliferation.|
| Insulin signaling pathway|
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Western blot analysis of lipe in human lymph node tissue lysate with lipe antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry of lipe in human lymph node tissue with lipe antibody at 2.5 ug/ml.