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Home Antibody All anti-LIPE antibodies

Anti-LIPE Antibody EPR2330


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against LIPE (Clone EPR2330)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417354) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues surrounding Serine 855 of human HSL was used as an immunogen. The antibody only detects HSL phosphorylated on Serine 855.
Clone NameEPR2330 IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1: 1,000~5,000
Predicted MW Explanation 117 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Rat

Reference Data

Target NameHomo sapiens lipase, hormone-sensitive (LIPE)
Alternative NameAOMS4; HSL; LHS
Database LinkNP_005348
Entrez Gene 3991 Human
Entrez Gene 16890 Mouse
FunctionHormone-sensitive lipase (HSL) is a key enzyme in fatty acid mobilization, overall energy homeostasis, and possibly steroidogenesis. It is acutely controlled through reversible phosphorylation by catecholamines and insulin (1). HSL is the rate-limiting enzyme in hydrolysis of triglycerides in adipose tissue and of cholesteryl esters in steroidogenic tissues including the adrenals, ovaries, testes, and macrophages (2, 3). HSL activity has been positively correlated with free and esterified cholesterol ratios in seminiferous tubules (STf) and interstitial tissue (ITf) enriched fractions, but not with triglyceride levels, during testicular development. HSL is localized to elongated spermatids and Sertoli cells, where its distribution is stage-dependent, and within the cells lining the excurrent ducts of the testis. The HSL protein levels and enzymatic activity in ITf and STf were reported positively correlated with serum testosterone levels during development (4).
Related Pathway Insulin signaling pathway

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WB Image
Western blot - HSL/LIPE (phospho S855) antibody [EPR2330]; All lanes : Anti-Hormone sensitive lipase (phospho S855) antibody [EPR2330] at 1/5000 dilution.Lane 1 : Human skeletal muscle lysate, untreated.Lane 2 : Human skeletal muscle lysate, treated with LP.Lysates/proteins at 10 ug per lane.Secondary.HRP labeled goat anti-rabbit at 1/1000 dilution.Predicted band size : 117 , 83 kDa.Observed band size : 83 kDa .


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