Home Antibody All anti-LIN28 antibodies
Also for LIN28 (NM_024674)
|Lin28 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human Lin28.|
|WB, IHC, IF
||WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens lin-28 homolog A (C. elegans) (LIN28A)|
|CSDD1; LIN-28; lin-28A; LIN28; ZCCHC1|
|Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.|
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Western blot analysis of Lin28 in Raji cell lysate with Lin28 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of KLF4 in human spleen tissue with KLF4 antibody at 5 ug/mL.
Immunofluorescence of LIN28 in human spleen tissue with LIN28 antibody at 20 ug/mL.