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Anti-LIMK1 TRUEMAB Antibody Clone OTI 7C3

TrueMAB™ Antibodies - Made against Authentic Protein Antigens


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA503007 LIMK1 (LIM Kinase 1 ) mouse monoclonal antibody, clone OTI 7C3 (formerly 7C3) 100ul 325
In Stock
LC400838 LIMK1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF503007 Carrier-free (BSA/glycerol-free) LIMK1 mouse monoclonal antibody, clone OTI 7C3 (formerly 7C3) 100ug $450 3-4 weeks
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Also for LIMK1 (NM_002314)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human LIMK1 (NP_002305) produced in HEK293T cell.
Clone NameClone OTI 7C3 IsotypeIgG2b
Species ReactivityHuman Concentration0.62 mg/ml
Guaranteed Application *WB, IF, FC Suggested Dilutions WB 1:2000, IF 1:100, FLOW 1:100,
Predicted MW Explanation 72.4 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens LIM domain kinase 1 (LIMK1), transcript variant 1
Alternative NameLIMK; LIMK-1
Database LinkNP_002305
Entrez Gene 3984 Human
FunctionThere are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011].
Related PathwayProtein KinaseDruggable Genome Axon guidanceFc gamma R-mediated phagocytosisRegulation of actin cytoskeleton

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* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LIMK1 (RC218058, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LIMK1.
Anti-LIMK1 mouse monoclonal antibody (TA503007) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LIMK1(RC218058).
HEK293T cells transfected with either RC218058 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-LIMK1 antibody(TA503007), and then analyzed by flow cytometry.


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