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Home Antibody All anti-LIMK1 antibodies

Anti-LIMK1 PHOSPHO Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA325620
  • Rabbit Polyclonal LIMK1 (Thr508) Antibody (Phospho-specific)
100ul 325 In Stock
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WB(1)

OriGene Data

ImmunogenThe antiserum was produced against A synthesized peptide derived from human LIMK1 around the phosphorylation site of Threonine 508
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1
Guaranteed Application *WB Suggested DilutionsWB: 1:500-1:2000; IHC: 1:50-1:200
Predicted MW Explanation 70kDa
BufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.

Reference Data

Target NameHomo sapiens LIM domain kinase 1 (LIMK1), transcript variant 2
Alternative NameLIMK; LIMK-1
Database LinkNP_001191355
Entrez Gene 3984 Human
Entrez Gene 16885 Mouse
Entrez Gene 65172 Rat
FunctionThere are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Two splice variant have been identified.
Related PathwayProtein KinaseDruggable Genome Axon guidanceFc gamma R-mediated phagocytosisRegulation of actin cytoskeleton

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WB Image
Western blot analysis of LIMK1 phosphorylation expression in COLO205 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

 

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