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Home Antibody All anti-LGI3 antibodies

Anti-LGI3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306538
  • Rabbit Polyclonal LGI3 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC408334) , 20ug
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenLGI3 antibody was raised against a 12 amino acid peptide from near the center of human LGI3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens leucine-rich repeat LGI family, member 3 (LGI3)
Alternative NameLGIL4
Database LinkNP_644807
FunctionThe leucine-rich, glioma inactivated gene 3 (LGI3) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI3 have not been found to be associated with ADTLE. LGI3 expression is induced in rat astrocyte cultures by the amyloid beta (Ab) peptide and accumulated on neuronal plasma membranes of aged monkey brains and co-localized with Ab. Two isoforms of LGI3 are known to exist; this LGI3 antibody will recognize both. This LGI3 antibody is predicted to be specific to LGI3 and not recognize other LGI proteins. The observed higher molecular weight band may represent a post-translationally modified form of LGI3.
Related Pathway

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WB Image
Western blot analysis of LGI3 in human brain tissue lysate with LGI3 antibody at 1 µg/ml.

 

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