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 Home All anti-LGI1 antibodies

Anti-LGI1 Antibody

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SKU Description Amount Price Availability*  
TA306546
  • Rabbit Polyclonal LGI1 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401572) , 20ug
 100ug $325 3-7 Days
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
 30ul
$100
$50*		 In Stock
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* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
WB(1)

OriGene Data

ImmunogenLGI1 antibody was raised against a 13 amino acid peptide from near the amino terminus of human LGI1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column (Protein A or G Sepharose)

Reference Data

Target NameHomo sapiens leucine-rich, glioma inactivated 1 (LGI1)
Alternative NameADLTE; ADPAEF; ADPEAF; EPITEMPIN; EPT; ETL1; IB1099
Database LinkNP_005088
FunctionThe leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Two isoforms of LGI1 are known to exist, but the top band seen in the western blot is likely to be non-specific. This LGI1 antibody is predicted to be specific to LGI1 and not recognize other LGI proteins.
Related Pathway

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WB Image
Western blot analysis of LGI1 in mouse brain tissue lysate with LGI1 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.

 

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