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Anti-LEMD2 Antibody Polyclonal
Also for LEMD2 (NM_181336)
|LEMD2 antibody was raised against a 16 amino acid synthetic peptide near the center of human LEMD2.|
||WB: 1 - 2 ug/ml, ICC: 2.5 ug/ml, IF: 2.5 ug/ml
|LEMD2 Antibody is supplied in PBS containing 0.02% sodium azide.|
|LEMD2 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens LEM domain containing 2 (LEMD2), transcript variant 1|
Entrez Gene 221496 Human
Entrez Gene 224640 Mouse
|LEMD2 Antibody: The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm. One such protein, LEMD2 (LEM domain-containing protein 2), is a lamina-associated protein in the INM involved in nuclear structure organization, containing an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain. LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1 is required for myogenic differentiation. Mutations in LEMD2 are thought be among the possible causes of muscle disease. |
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Western blot analysis of LEMD2 in 293 cell lysate with LEMD2 antibody at (A) 1 and (B) 2 ug/mL.
Immunofluorescence of LEMD2 in 3T3 cells with LEMD2 antibody at 20 ug/mL.