Lipocalin-2 is an adipokine that belongs to the superfamily of lipocalins, which seems to affect glucose metabolism and insulin sensitivity (1). It is an iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Lipocalin-2 binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell (2). It is highly expressed in adipose tissue in vivo and in vitro, and its secretion is regulated by the activation of inflammation and infection (1).
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