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Anti-LAS1L Antibody EPR8989(B)


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against LAS1L
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human LAS1L was used as an immunogen.
Clone NameEPR8989(B) IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
BufferpH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens LAS1-like (S. cerevisiae) (LAS1L), transcript variant 2
Alternative NamedJ475B7.2; Las1-like
Database LinkNP_001164120
Entrez Gene 81887 Human
FunctionLAS1L is a nuclear protein essential for cell proliferation and ribosome synthesis; particularly the biogenesis of the 60S ribosomal subunits (1, 2). It is also required for maturation of the 28S rRNA (1). Depletion of LAS1L has shown to cause nucleolar disorganization and inhibit cell proliferation characterized by a p53-dependent G1 cell by cycle arrest (2).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-LAS1L antibody [EPR8989(B)]; All lanes : Anti-LAS1L antibody [EPR8989(B)] at 1/1000 dilution.Lane 1 : HCT116 cell lysate.Lane 2 : 293T cell lysate.Lane 3 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 83 kDa.
Assay Image
Other-Anti-LAS1L antibody [EPR8989(B)](TA310652); Equilibrium disassociation constant (KD)..
FC Image
Flow Cytometry - Anti-LAS1L antibody [EPR8989(B)]; Flow cytometrical analysis of LAS1L in permeabilized HeLa cells labelled with TA310652 at a 1/10 dilution (red), or with Rabbit IgG negative control (green).


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