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Home Antibody All anti-LAMP1 antibodies

Anti-LAMP1 Antibody EPR4204

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307209
  • Rabbit monoclonal antibody against LAMP1(clone EPR4204)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC417223) , 20ug
100ul $325 In Stock
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WB(1)
IHC(1)
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Also for LAMP1 (NM_005561)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human LAMP1 was used as an immunogen.
Clone NameEPR4204 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens lysosomal-associated membrane protein 1 (LAMP1)
Alternative NameCD107a; LAMPA; LGP120
Database LinkNP_005552
FunctionLysosome associated membrane glycoprotein 1 (LAMP1) is a type 1 integral membrane protein that is involved in lysosomal exocytosis, movement of lysosomes along microtubules, and fusion of phagosomes with lysosomes (1). The cytoplasmic tail of LAMP1 contains a tyrosine-based motif that mediates sorting in the trans-Golgi network and rapid internalization at the plasma membrane (2). This motif is required for intracellular targeting to lysosomes (2). Furthermore, LAMP1 presents carbohydrate ligands to selectins and is implicated in tumor cell metastasis (3). LAMP1 shares considerable sequence homology with LAMP2, another member of the LAMP family (4). They both have similar domain structures and biochemical properties, since they protect the lysosomal membrane from hydrolytic damage (4). LAMP1 is known to be more abundant than LAMP2, although the loss of LAMP1 causes LAMP2 levels to be elevated (4). The two LAMP proteins are used as membrane markers for intracellular infection (5).
Related Pathway

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WB Image
Western blot - LAMP1 antibody [EPR4204]; All lanes : Anti-LAMP1 antibody [EPR4204] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : JAR cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : A431 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 45 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - LAMP1 antibody [EPR4204]; Immunohistochemical analysis of LAMP1 in paraffin embedded Human kidney tissue, using TA307209 at a dilution of 1/100.

 

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