Home Antibody All anti-LAMP1 antibodies
Also for LAMP1 (NM_005561)
|LAMP-1 antibody was raised against a 15 amino acid peptide from near the center of human LAMP-1.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||ELISA, WB: 1 - 2 ug/ml, IHC: 20 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens lysosomal-associated membrane protein 1 (LAMP1)|
|CD107a; LAMPA; LGP120|
Entrez Gene 3916 Human
Entrez Gene 16783 Mouse
Entrez Gene 25328 Rat
|Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) and is negatively regulated by TOR (Target of rapamycin) (3). A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome (4,5). LAMP-1 shares much homology to LAMP-2 and is thought to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression (6). However, the loss of both proteins resulted in embryonic lethality (7), suggesting that each protein possesses some unique and necessary functions.|
|ES Cell Differentiation/IPSTransmembrane Lysosome|
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Western blot analysis of LAMP-1 in EL4 cell lysate with LAMP-1 antibody at (A) 1 and (B) 2 ug/mL.
Immunofluorescence of LAMP-1 in human colon tissue with LAMP-1 antibody at 20 ug/mL.