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Home Antibody All anti-LAMC1 antibodies

Anti-LAMC1 Antibody EPR8217

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310967
  • Rabbit Monoclonal antibody against Laminin Gamma 1 (LAMC1)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419413) , 20ug
100ul 325 In Stock
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WB(1)
FC(1)
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Also for LAMC1 (NM_002293)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Laminin Gamma 1 was used as an immunogen.
Clone NameEPR8217 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for ICC,IHC-P or IP.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens laminin, gamma 1 (formerly LAMB2) (LAMC1)
Alternative NameLAMB2
Database LinkNP_002284
FunctionLaminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. Laminin Gamma 1 is the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this protein also suggested that it had diverged considerably from the beta chain proteins. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that Laminin Gamma 1 is necessary for laminin heterotrimer assembly (1).
Related Pathway
Focal Adhesion

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Laminin gamma 1 antibody [EPR8217]; All lanes : Anti-Laminin gamma 1 antibody [EPR8217] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : JAR cell lysate.Lane 3 : A431 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 178 kDa.
FC Image
Flow Cytometry - Anti-Laminin gamma 1 antibody [EPR8217]; Flow Cytometry analysis of permeabilized A431 cells labelling Laminin gamma 1 with TA310967 at 1/10 dilution (red). Rabbit IgG negative control shown in green.

 

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