Anti-LAMB1 Antibody, EPR3190(2)

Also for LAMB1 (NM_002291)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in human Laminin Beta 1 was used as an immunogen.
Clone Name	EPR3190(2)	Isotype	Rabbit IgG
Species Reactivity	Human, Mouse, Rat	Concentration
Guaranteed Application *	WB, FC	Suggested Dilutions	FC: 1:100 - 500, WB: 1:1,000-10,000,
Buffer	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens laminin, beta 1 (LAMB1)
Alternative Name	CLM
Database Link	NP_002282
Function	Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms, which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. Some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. The beta chain isoform, laminin beta 1, has 7 structurally distinct domains that it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. It is involved in cell attachment and chemotaxis; binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.
Related Pathway	Focal Adhesion

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WB Image

Western blot analysis on (A) fetal kidney and (B) A431 lysates using anti-Laminin Beta 1 RabMAb .

FC Image

Flow cytometric analysis of permeabilized A431 cells using anti-Laminin Beta 1 RabMAb (red) or a rabbit IgG (negative) (green).

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OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

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FITC
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OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-LAMB1 Antibody EPR3190(2)

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data