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Anti-KSR1 PHOSPHO Antibody EPR2359(2)
Also for KSR1 (NM_014238)
|A phospho specific peptide corresponding to residues surrounding Serine 392 of human KSR1 was used as an immunogen. This antibody only detects KSR1 phosphorylated at Serine 392.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
|Homo sapiens kinase suppressor of ras 1 (KSR1)|
Entrez Gene 8844 Human
|Kinase suppressor of Ras (KSR) is a conserved component of the Ras pathway that interacts directly with MEK and MAPK. It has been shown that KSR1 translocates from the cytoplasm to the cell surface in response to growth factor treatment and that this process is regulated by MARK3 (1). MARK3 seems to be a positive regulator of the beta-catenin pathway and an inhibitor of the JNK pathway. These findings show that MARK3, a regulator of polarity, is also a modulator of Wnt-beta-catenin signaling, indicating a link between two important developmental pathways (2). C-TAK1 constitutively associates with mammalian KSR1 and phosphorylates serine 392 to confer 14-3-3 binding and cytoplasmic sequestration of KSR1 in unstimulated cells (1).|
|Protein KinaseDruggable Genome |
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Western blot - Anti-KSR1 (phospho S392) antibody [EPR2359(2)]; All lanes : Anti-KSR1 (phospho S392) antibody [EPR2359(2)] at 1/1000 dilution.Lane 1 : 293T cell lysate, untreated.Lane 2 : 293T cell lysate treated with Calyculin A.Lysates/proteins at 10 ug per lane.Secondary.Standard HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 102 kDa.
Other-Anti-KSR1 (phospho S392) antibody [EPR2359(2)](TA310649); Equilibrium disassociation constant (KD)..