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Anti-KSR1 Phospho Antibody EPR2359(2)
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Also for KSR1 (NM_014238)
|A phospho specific peptide corresponding to residues surrounding Serine 392 of human KSR1 was used as an immunogen. This antibody only detects KSR1 phosphorylated at Serine 392.|
||WB: 1:1,000 - 10,000;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens kinase suppressor of ras 1 (KSR1)|
|Kinase suppressor of Ras (KSR) is a conserved component of the Ras pathway that interacts directly with MEK and MAPK. It has been shown that KSR1 translocates from the cytoplasm to the cell surface in response to growth factor treatment and that this process is regulated by MARK3 (1). MARK3 seems to be a positive regulator of the beta-catenin pathway and an inhibitor of the JNK pathway. These findings show that MARK3, a regulator of polarity, is also a modulator of Wnt-beta-catenin signaling, indicating a link between two important developmental pathways (2). C-TAK1 constitutively associates with mammalian KSR1 and phosphorylates serine 392 to confer 14-3-3 binding and cytoplasmic sequestration of KSR1 in unstimulated cells (1).|
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Western blot analysis on 293T cell lysates using anti-Phospho-KSR1 (pS392) RabMAb. Cells were either (A) untreated or (B) treated with Calyculin A.