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Anti-KRT8 PHOSPHO Antibody EP1630
Also for KRT8 (NM_002273)
|A synthetic peptide corresponding to residues surrounding Serine 431 of human Cytokeratin 8 was used as an immunogen. The antibody only detects Cytokeratin 8 phosphorylated at Serine 431.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:50000; IP: 1:50; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt.
|Homo sapiens keratin 8 (KRT8), transcript variant 2|
|CARD2; CK-8; CK8; CYK8; K2C8; K8; KO|
|Keratin polypeptides 8 and 18 (K8/18) are intermediate filament phosphoglycoproteins that are expressed preferentially in glandular epithelia. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells (1-3). Together with actin microfilaments and microtubules, keratin filaments make up the cytoskeletons of vertebrate epithelial cells, forming alpha-helical coiled-coil dimers which associate laterally and end-to-end to form 10-nm diameter filaments (4). |
EGFR1 Signaling Pathway
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Western blot - Cytokeratin 8 (phospho S431) antibody [EP1630]; All lanes : Anti-Cytokeratin 8 (phospho S431) antibody [EP1630] at 1/10000 dilution.Lane 1 : HeLa lysates, untreated.Lane 2 : HeLa lysates, treated with FBS and Calyculin A.Lysates/proteins at 10 µg per lane.Predicted band size : 54 kDa.Observed band size : 52 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cytokeratin 8 (phospho S431) antibody [EP1630]; TA307459 at 1/100 dilution staining Cytokeratin 8 in Human ductal breast carcinoma by Immunohistochemistry, Paraffin-embedded tissue.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cytokeratin 8 (phospho S431) antibody [EP1630]; TA307459 at 1/100 dilution staining Cytokeratin 8 in Human stomach adenocarcinoma by Immunohistochemistry, Paraffin-embedded tissue.