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Home Antibody All anti-KRT8 antibodies

Anti-KRT8 PHOSPHO Antibody EP1630

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307459
  • Rabbit monoclonal antibody against Cytokeratin 8 Phospho (pS431) (clone EP1630 ) (Phospho-Specific)
100ul $325 3-7 Days
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WB(1)
IHC(2)
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Also for KRT8 (NM_002273)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding Serine 431 of human Cytokeratin 8 was used as an immunogen. The antibody only detects Cytokeratin 8 phosphorylated at Serine 431.
Clone NameEP1630 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:50; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens keratin 8 (KRT8), transcript variant 2
Alternative NameCARD2; CK-8; CK8; CYK8; K2C8; K8; KO
Database LinkNP_002264
FunctionKeratin polypeptides 8 and 18 (K8/18) are intermediate filament phosphoglycoproteins that are expressed preferentially in glandular epithelia. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells (1-3). Together with actin microfilaments and microtubules, keratin filaments make up the cytoskeletons of vertebrate epithelial cells, forming alpha-helical coiled-coil dimers which associate laterally and end-to-end to form 10-nm diameter filaments (4).
Related Pathway
EGFR1 Signaling Pathway

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WB Image
Western blot - Cytokeratin 8 (phospho S431) antibody [EP1630]; All lanes : Anti-Cytokeratin 8 (phospho S431) antibody [EP1630] at 1/10000 dilution.Lane 1 : HeLa lysates, untreated.Lane 2 : HeLa lysates, treated with FBS and Calyculin A.Lysates/proteins at 10 µg per lane.Predicted band size : 54 kDa.Observed band size : 52 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cytokeratin 8 (phospho S431) antibody [EP1630]; TA307459 at 1/100 dilution staining Cytokeratin 8 in Human ductal breast carcinoma by Immunohistochemistry, Paraffin-embedded tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cytokeratin 8 (phospho S431) antibody [EP1630]; TA307459 at 1/100 dilution staining Cytokeratin 8 in Human stomach adenocarcinoma by Immunohistochemistry, Paraffin-embedded tissue.

 

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