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Anti-KRT5 Antibody EPR1600Y


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against KRT5 (Clone EPR1600Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400149) , 20ug Explanation
100ul 325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the head region of human cytokeratin 5 was used as an immunogen.
Clone NameEPR1600Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1: 10,000; IHC: 1: 100; ICC: 1:250; IP: 1:60
Predicted MW Explanation 62 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens keratin 5 (KRT5)
Alternative NameCK5; DDD; DDD1; EBS2; K5; KRT5A
Database LinkNP_000415
Entrez Gene 3852 Human
FunctionKeratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. The mitotically active basal layers of most stratified squamous epithelia express 10 to 30% of their total protein as keratin. The two keratins specifically expressed in these cells are the type II keratin CK-5 and its corresponding partner, type I keratin CK-14, both of which are essential for the formation of 8-nm filaments (1). CK-5 and calretinin have been useful in different studies as immunohistochemical markers suggestive of mesothelioma, and their expression is analyzed for the histological differential diagnosis with adenocarcinomas, especially when confronting with metastatic tumors of unknown origin (2). Loss-of-function mutations in the keratin 5 gene (KRT5) affected family members and in six unrelated patients with Dowling-Degos disease (DDD), an autosomal dominant genodermatosis. This suggests a crucial role for keratins in the organization of cell adhesion, melanosome uptake, organelle transport, and nuclear anchorage (3).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Cytokeratin 5 antibody [EPR1600Y]; Anti-Cytokeratin 5 antibody [EPR1600Y] at 1/10000 dilution + A431 cell lysate at 10 ug.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 62 kDa.Observed band size : 62 kDa.
Assay Image
Other-Anti-Cytokeratin 5 antibody [EPR1600Y](TA301148); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cytokeratin 5 antibody [EPR1600Y]; TA301148 at 1/100 dilution staining Cytokeratin 5 in human squamous cervical carcinoma by Immunohistochemistry, Paraffin-embedded tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Cytokeratin 5 antibody [EPR1600Y](TA301148); Fluorescent immunohistochemical analysis of paraffin-embedded human cervical carcinoma tissue using TA301148. Green-CK5 red-PI.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 5 antibody [EPR1600Y]; Fluorescent immunohistochemical analysis of paraffin-embedded human cervical carcinoma using TA301148. Green-CK5 red-PI.


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