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Home Antibody All anti-KRAS antibodies

Anti-KRAS Antibody EPR3255

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307023
  • Rabbit monoclonal antibody against Ras(clone EPR3255)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC409579) , 20ug Explanation
100ul 325 In Stock
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WB(1)
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Also for KRAS (NM_033360)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human K-Ras was used as an immunogen. This antibody also detects H-Ras and N-Ras.
Clone NameEPR3255 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC: 1:50 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens Kirsten rat sarcoma viral oncogene homolog (KRAS), transcript variant a
Alternative NameC-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS1; KRAS2; NS; NS3; RASK2
Database LinkNP_203524
Entrez Gene 3845 Human
Entrez Gene 16653 Mouse
Entrez Gene 24525 Rat
FunctionRas, a signal transducer, was first characterized as the transforming genes of Harvey & Kristen sarcoma virus (1). The Ras family (H-Ras, N-Ras, and K-Ras) regulates cell growth, differentiation and apoptosis (2). Switching from an active or resting state, Ras can either bind GTP or GDP respectively. In the triphosphate conformation, Ras will interact with GTPase activating protein (GAP) to increase its activity (3). Mutations in any of the three isoforms can convert these proteins into active oncogenes. Additionally, Ras mutations are found in 30 % of all human cancer (4).
Related PathwayDruggable Genome MAPK signaling pathwayErbB signaling pathwayChemokine signaling pathwayDorso-ventral axis formationAxon guidanceVEGF signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Ras antibody [EPR3255]; All lanes : Anti-Ras antibody [EPR3255] at 1/1000 dilution.Lane 1 : 293T cell lysate.Lane 2 : SH-SY5Y cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 22 kDa.

 

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