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Home Antibody All anti-KPNA6 antibodies

Anti-KPNA6 Antibody Polyclonal

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA319867 Rabbit Polyclonal KPNA6 Antibody 100ug $325 3-7 Days
LC402193 KPNA6 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IF(1)
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Also for KPNA6 (NM_012316)
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OriGene Data

ImmunogenKPNA6 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human KPNA6.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, IF: 20 ug/ml
BufferKPNA6 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification KPNA6 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens karyopherin alpha 6 (importin alpha 7) (KPNA6)
Alternative NameIPOA7; KPNA7
Database LinkNP_036448
Entrez Gene 23633 Human
Entrez Gene 16650 Mouse
Entrez Gene 362607 Rat
FunctionKPNA6 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of KPNA6 in 293 cell lysate with KPNA6 antibody at 1 ug/mL.
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Immunofluorescence of KPNA6 in 293 cells with KPNA6 antibody at 20 ug/mL.
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