Home Antibody All anti-KITLG antibodies
Also for KITLG (NM_000899)
|SCF antibody was raised against an 18 amino acid peptide from near the center of human SCF.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens KIT ligand (KITLG), transcript variant b|
|FPH2; Kitl; KL-1; MGF; SCF; SF; SHEP7|
|Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-g, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.|
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
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Western blot analysis of SCF in rat brain tissue lysate with SCF antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of SCF in mouse brain tissue with SCF antibody at 2.5 ug/ml.