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Home Antibody All anti-KITLG antibodies

Anti-KITLG Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306779
  • Rabbit Polyclonal SCF Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400322) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for KITLG (NM_000899)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSCF antibody was raised against an 18 amino acid peptide from near the center of human SCF.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens KIT ligand (KITLG), transcript variant b
Alternative NameFPH2; Kitl; KL-1; MGF; SCF; SF; SHEP7
Database LinkNP_000890
Entrez Gene 4254 Human
Entrez Gene 60427 Rat
FunctionStem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-g, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
Related PathwayTransmembraneDruggable Genome Cytokine-cytokine receptor interactionHematopoietic cell lineageMelanogenesisPathways in cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of SCF in rat brain tissue lysate with SCF antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of SCF in mouse brain tissue with SCF antibody at 2.5 ug/ml.

 

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