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Anti-KIT Antibody Y145
|A synthetic peptide corresponding to residues in the C-terminus (cytoplasmic domain) of human c-Kit was used as an immunogen. The antibody does not cross-react with other CSF-1/PDGF receptor family member.|
|Human, Marmoset (common) (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1,000; IHC: 1:50-100
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), transcript variant 1|
|C-Kit; CD117; PBT; SCFR|
|This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
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TA303564 showing positive staining in Lung adenocarcinoma tissue.
TA303564 showing positive staining in Glioma tissue
TA303564 showing positive staining in Seminoma tissue
TA303564 showing positive staining in Breast carcinoma tissue.
TA303564 showing positive staining in Ovarian carcinoma tissue.
IHC-P image of c-Kit (TA303564) staining on adult marmoset testis. The sections were fixed in Formaldehyde and underwent heat mediated antigen retrieval, using Dako antigen retrieval solution. The sections were then blocked in 5% milk for 30 mins at 25°C. The primary antibody was added at a 1:100 dilution, and then incubated for 18 hours at 4oC. Dapi was used to stain the nuclei (blue).
Flow cytometric analysis of permeabilized Hela cells using TA303564 at 1/350 RabMAb (red) or a rabbit IgG (negative) (green).
Flow cytometric analysis of permeabilized K562 cells using TA303564 at 1/350 RabMAb (red) or a rabbit IgG (negative) (green).