Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
KIF3A, a member of the kinesin-like protein family, is a microtubule-based anterograde translocator for membranous organelles (1). The KIF3A motor comprises a heterodimer of the motor proteins KIF3A and KIF3B and an associated protein, KAP3, which binds to the tail ends of KIF3A and KIF3B (2). This heterodimer possesses a plus-end-directed microtubule sliding activity that uses energy derived from ATP hydrolysis. On the other hand, KAP3 links KIF3A/3B with various cargo proteins, including fodrin and the tumor suppressor adenomatous polyposis coli (APC). By binding to fodrin, the KIF3A/3B heterotrimer transports fodrin-associating vesicles that are important for neurite building (3).
Related Pathway
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