SAM68 (Src-associated protein in mitosis 68 kDa) is a member of the signal transduction and activation of RNA family of KH domain-containing RNA binding proteins (1). It is a major substrate of the Src tyrosine kinase in mitotic cells, having a tyrosine-rich C-terminal region and six polyproline (SH3-binding) sites, many of which are located in an amino-terminal region. Once phosphorylated, SAM68 functions as an adaptor protein in signal transduction cascades by binding to SH2- and SH3-domain containing proteins (2). Tyrosine phosphorylation also negatively regulates the nucleic acid binding properties of SAM68 (3).
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