Home Antibody All anti-KEAP1 antibodies
Anti-KEAP1 Antibody Polyclonal
Also for KEAP1 (NM_012289)
|KEAP1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human KEAP1.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml, IF: 20 ug/ml
|KEAP1 Antibody is supplied in PBS containing 0.02% sodium azide.|
|KEAP1 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens kelch-like ECH-associated protein 1 (KEAP1), transcript variant 2|
Entrez Gene 9817 Human
Entrez Gene 50868 Mouse
Entrez Gene 117519 Rat
|KEAP1 Antibody: KEAP1 (kelch-like ECH-associated protein 1) is a stress sensing adaptor for the Cullin3 (Cul3)-dependent E3 ubiquitin ligase complex that negatively regulates NRF2 (NF-E2-related factor 2) and plays a role in the oxidative stress response. It targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome. KEAP1 contains an amino terminal BTB/POZ domain and a carboxyl terminal KELCH domain which are required for interaction with NRF2, and in binding Cul3-E3 ubiquitin ligase. Altered expression of NRF2 is associated with chronic obstructive pulmonary disease (COPD). KEAP1 also targets the down regulation of NF-κB activity by targeting IKKβ degradation. Mutation of the KEAP1 gene is found in lung cancer.|
|Transcription Factors Ubiquitin mediated proteolysis|
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Western blot analysis of KEAP1 in human lung tissue lysate with KEAP1 antibody at (A) 1 and (B) 2 ug/mL.
Immunofluorescence of KEAP1 in human lung tissue with KEAP1 antibody at 20 ug/mL.