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Home Antibody All anti-KDM4B antibodies

Anti-KDM4B Antibody

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SKU Description Amount Price Availability*  
TA306832
  • Rabbit Polyclonal JMJD2B Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC414852) , 20ug
100ug $325 In Stock
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WB(1)

OriGene Data

ImmunogenJMJD2B antibody was raised against a 16 amino acid peptide from near the center of human JMJD2B.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens lysine (K)-specific demethylase 4B (KDM4B)
Alternative NameJMJD2B; TDRD14B
Database LinkNP_055830
FunctionMembers of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. Like other members of the JMJD1 and JMJD2 families, JMJD2B is a histone demethylase, but is reported to be a very poor enzyme. Similar to JMJD1A, JMJD2B is a transcriptional target of the hypoxia-inducible factor (HIF), and hypoxic cells express elevated levels of the JMJD2B mRNA and protein. Both JMJD1A and JMJD2B retain their histone demethylase activity in hypoxic conditions, suggesting that this activity of JMJD2B might play a role in the hypoxic gene expression program.
Related Pathway

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WB Image
Western blot analysis of JMJD2B in A20 cell lysate with JMJD2B antibody at (A) 1 and (B) 2 µg/ml.

 

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