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Anti-KDM3B Antibody

WB(1)

IHC(1)

Gene Name Homo sapiens lysine (K)-specific demethylase 3B (KDM3B) Synonyms: 5qNCA; C5orf7; JMJD1B; NET22 Immunogen JMJD1B antibody was raised against a 20 amino acid peptide from near the center of human JMJD1B. Buffer PBS containing 0.02% sodium azide. Clone Name Isotype IgG Species Reactivity Human, Mouse, Rat Concentration 1ug/ul Purification Affinity chromatography purified via peptide column (Protein A or G Sepharose) Guaranteed Application * WB, IHC Suggested Dilutions WB: 1 - 2 ug/ml Background The jumonji domain containing 1B protein (JMJD1B) was originally discovered as a candidate for the myeloid leukemia tumor suppressor gene. Besides CD34+ cells and acute myeloid leukemia (AML) cell lines, JMJD1B mRNA is highly expressed in liver, heart, kidney, skeletal muscle, and placenta tissues. The JMJD1B gene is localized to a region of chromosome 5q31, which is frequently deleted in myeloid leukemias and myelodysplasias and expression of JMJD1B in a del(5q) cell line results in suppression of clonogenic growth suggesting that JMJD1B may function as a tumor suppressor. In contrast, JMJD1B gene copy number and mRNA expression level was increased in several non-small cell lung cancers indicating that the role of JMJD1B in cancer formation and progression is more complex than originally postulated. At least three isoforms of JMJD1B are known to exist. This antibody will not cross-react with JMJD1A or JMJD1C. Related Pathway

Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • KDM3B - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • KDM3B - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Kdm3b - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • KDM3B - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Kdm3b - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens lysine (K)-specific demethylase 3B (KDM3B) as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens lysine (K)-specific demethylase 3B (KDM3B) as transfection-ready DNA Related cDNA Clones • Homo sapiens lysine (K)-specific demethylase 3B (KDM3B) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)