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Home Antibody All anti-KCNT2 antibodies

Anti-KCNT2 Antibody S11-33

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326399
  • Mouse monoclonal Slo2.1 Antibody
100µg $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenFusion protein amino acids 564-624 of mouse Slo2.1 (Slick),
Clone NameS11-33 IsotypeIgG1
Species ReactivityMouse, Rat Concentration1mg/mL
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1-10ug/ml, IHC: 0.1-1.0ug/ml, IF: 1.0-10ug/ml
BufferPBS pH7.4, 50% glycerol, 0.09% sodium azide
Purification Protein G Purified
Note Detects ~140kDa.

Reference Data

Target NameHomo sapiens potassium channel, subfamily T, member 2 (KCNT2), transcript variant 1
Alternative NameKCa4.2; SLICK; SLO2.1
Database LinkNP_940905
FunctionIon channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient . They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels .Slo2.1 is a novel member of the mammalian Slo potassium channel gene family . The slick channel is activated by intracellular Na+ and Cl- and is inhibited by intracellular ATP. It is also widely expressed in the CNS and detected in the heart .
Related Pathway

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WB Image
Western blot analysis of Slo2.1 (SLICK) in rat brain membrane lysates using a 1:1000 dilution of the antibody
IHC Image
IHC analysis of Slo2.1 in mouse backskin sections using the antibody

 

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