Home Antibody All anti-KCNQ4 antibodies
Anti-KCNQ4 Antibody S43-6
Also for KCNQ4 (NM_004700)
|Fusion protein amino acids 2-77 of human KCNQ4, accession number P56696|
|Human, Mouse, Rat
||WB, IP, ICC
|PBS, 50% glycerol|
|Homo sapiens potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4), transcript variant 1|
|DFNA2; DFNA2A; KV7.4|
|The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
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Western blot analysis of KCNQ4 in rat tissue lysates using a 1:1000 dilution of SMC-309.