Home Antibody All anti-KCNK18 antibodies
Also for KCNK18 (NM_181840)
|TRESK antibody was raised against a 17 amino acid peptide from near the center of human TRESK.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens potassium channel, subfamily K, member 18 (KCNK18)|
|K2p18.1; MGR13; TRESK; TRESK-2; TRESK2; TRIK|
|TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.|
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Western blot analysis of TRESK in rat brain tissue lysate with TRESK antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of TRESK in rat brain tissue with TRESK antibody at 5 ug/mL.