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Home Antibody All anti-KCNK18 antibodies

Anti-KCNK18 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306901 Rabbit Polyclonal TRESK Antibody 100ug $325 3-7 Days
LC403632 KCNK18 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenTRESK antibody was raised against a 17 amino acid peptide from near the center of human TRESK.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens potassium channel, two pore domain subfamily K, member 18 (KCNK18)
Alternative NameK2p18.1; MGR13; TRESK; TRESK-2; TRESK2; TRIK
Database LinkNP_862823
Entrez Gene 338567 Human
Entrez Gene 332396 Mouse
Entrez Gene 445371 Rat
FunctionTRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.
Related PathwayIon Channels: PotassiumTransmembrane

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of TRESK in rat brain tissue lysate with TRESK antibody at (A) 1 and (B) 2 ug/mL.
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Immunohistochemistry of TRESK in rat brain tissue with TRESK antibody at 5 ug/mL.
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