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Anti-KAL1 Antibody Polyclonal
Also for KAL1 (NM_000216)
|Anosmin antibody was raised against an 18 amino acid synthetic peptide near the center of human Anosmin.|
||WB: 1 ug/ml, ICC: 5 ug/ml, IF: 20 ug/ml
|Anosmin Antibody is supplied in PBS containing 0.02% sodium azide.|
|Anosmin Antibody is affinity chromatography purified via peptide column.
|Homo sapiens Kallmann syndrome 1 sequence (KAL1)|
|ADMLX; HH1; HHA; KAL; KALIG-1; KMS; WFDC19|
Entrez Gene 3730 Human
|Anosmin Antibody: Mutations in Anosmin-1, an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron. Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex.|
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Western blot analysis of Anosmin in MCF7 cell lysate with Anosmin antibody at 1 ug/mL.
Immunofluorescence of Anosmin in MCF7 cells with Anosmin antibody at 20 ug/mL.