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Home Antibody All anti-JUN antibodies

Anti-JUN PHOSPHO Antibody EPR2236

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307462
  • Rabbit monoclonal antibody against c-Jun Phospho (pT91) (clone EPR2236 ) (Phospho-Specific)
100ul 325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding Threonine 91 of human c-Jun was used as an immunogen. The antibody only recognizes c-Jun phosphorylated at Threonine 91.
Clone NameEPR2236 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:2000; IP: 1:20
Predicted MW Explanation 36 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens jun proto-oncogene (JUN)
Alternative NameAP-1; AP1; c-Jun
Database LinkNP_002219
Entrez Gene 3725 Human
Entrez Gene 16476 Mouse
Entrez Gene 24516 Rat
Functionc-Jun is a major component of the heterodimeric transcription factor AP-1 and is essential for embryonic development (1). It mediates several cellular processes, including proliferation and survival, and is upregulated in many carcinomas (2). Transactivation of c-Jun is regulated by Jun-N-terminal Kinases (JNKs) through phosphorylation at Serine 63 and 73, as well as at threonine 91 and 93 (3). Evidence supports that phosphorylation in NH2-terminal residues of c-Jun stimulates the dephosphorylation of the COOH-terminal sites, and consequently increases the DNA-binding activity of the transcription factor (4). c-Jun N-terminal kinase (JNK) isoforms are required for the phosphorylation of Threonine 91 and 93 in response to anisomycin in macrophages and TNF-alpha or anisomycin in fibroblasts (5).
Related PathwayES Cell Differentiation/IPSTranscription FactorsDruggable Genome MAPK signaling pathwayErbB signaling pathwayWnt signaling pathwayFocal adhesionToll-like receptor signaling pathwayT cell receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - c-Jun (phospho T91) antibody [EPR2236]; All lanes : Anti-c-Jun (phospho T91) antibody [EPR2236] at 1/2000 dilution.Lane 1 : lysate from 3T3 cells .Lane 2 : lysate from 3T3 cells treated with Anisomycin.Lysates/proteins at 10 ug per lane.Predicted band size : 36 kDa.Observed band size : 50 kDa .

 

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