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Home Antibody All anti-JPH4 antibodies

Anti-JPH4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306682
  • Rabbit Polyclonal JPH2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC432005) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for JPH4 (NM_001146028)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenJPH2 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human JPH2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens junctophilin 4 (JPH4), transcript variant 2
Alternative NameJP4; JPHL1
Database LinkNP_001139500
FunctionJunctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH2-null mice died of embryonic cardiac arrest and human patients with mutations in the JPH2 gene showed hypertrophic cardiomyopathy, demonstrating the importance of this protein. Multiple isoforms of JPH2 are known to exist.
Related Pathway

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WB Image
Western blot analysis of JPH2 in 293 cell lysate with JPH2 antibody at 2 µg/ml in (A) the absence and (B) the presence of blocking peptide.

 

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