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Home Antibody All anti-JNK1 antibodies

Anti-JNK1 TRUEMAB Antibody Clone OTI3B4H9

TrueMAB™ Antibodies - Made against Authentic Protein Antigens


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA500276 anti-JNK1 (MAPK8) mouse monoclonal antibody, clone OTI3B4H9 (formerly 3B4H9) 100ul 325
2 Weeks
LC400970 MAPK8 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF500276 Carrier-free (BSA/glycerol-free) anti-JNK1 (MAPK8) mouse monoclonal antibody, clone OTI3B4H9 (formerly 3B4H9) 100ug $450 3-4 weeks
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OriGene Data

ImmunogenRecombinant protein expressed in E.coli corresponding to amino acids 1-384 of human JNK1
Clone NameClone OTI3B4H9 IsotypeIgG2a
Species ReactivityHuman Concentration0.4 mg/ml
Guaranteed Application *WB Suggested DilutionsWB 1:1000
Predicted MW Explanation 44 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Puridied form mouse ascites fluids

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-a1
Alternative NameJNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c
Database LinkNP_002741
Entrez Gene 5599 Human
FunctionJNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK1 is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of JNK1 by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. JNK1 is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of JNK1 gene suggested that it play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported
Related PathwayProtein KinaseES Cell Differentiation/IPSDruggable Genome MAPK signaling pathwayErbB signaling pathwayWnt signaling pathwayFocal adhesionToll-like receptor signaling pathwayNOD-like receptor signaling pathwayMore Pathways >>

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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY JNK1 (RC218407, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-JNK1 .


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