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Anti-JAK3 Antibody EPR908(2)
Also for JAK3 (NM_000215)
|A synthetic peptide corresponding to residues on the N-terminus in human JAK3 was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||ICC: 1:250 - 500, WB: 1:1,000-10,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens Janus kinase 3 (JAK3)|
|JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK|
|JAK3 is a member of the Janus family (JAK) tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. The JAK family is constitutively associated with cytokine receptors; upon binding to the receptor, the cytokine becomes phosphorylated (1). JAK also phosphorylates the cytokine receptor on tyrosine (Tyr) residues that serve as docking sites for cytoplasmic signal transducers and activators of transcription (STAT) proteins (2). Activated STATs translocate to the nucleus to mediate gene transcription (1). JAK3 is unique among JAK family members because it serves a function in normal lymphocyte development. In addition, JAK3 is the only one that interacts with the common gamma chain of the following Interleukin receptors: IL-2, IL-4, IL-7, IL-9, and IL-15 receptors (3). Loss of JAK3 function causes a severe block in T-cell and natural killer (NK) cell development (4). Defects in JAK3 are a cause of severe combined immunodeficiency (SCID), characterized by an absence of T-cell-mediated cellular immunity (5).|
Jak-STAT signaling pathway
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Western blot - JAK3 antibody [EPR908(2)]; All lanes : Anti-JAK3 antibody [EPR908(2)] at 1/1000 dilution.Lane 1 : IM-9 cell lysate.Lane 2 : TF-1 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 125 kDa.