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Anti-JAK2 Antibody EPR108(2)
Also for JAK2 (NM_004972)
|A synthetic peptide corresponding to residues on the C-terminus in human JAK2 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC: 1:100 - 1:500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens Janus kinase 2 (JAK2)|
Entrez Gene 3717 Human
Entrez Gene 16452 Mouse
Entrez Gene 24514 Rat
|JAK2 is a member of the Janus family (JAK) tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction (1). The JAK family is constitutively associated with cytokine receptors; upon ligand binding, JAK phosphorylates the receptor. JAK also phosphorylates the cytokine receptor on tyrosine (Tyr) residues that serve as docking sites for cytoplasmic signal transducers and activators of transcription (STAT) proteins (2). Activated STATs translocate to the nucleus to mediate gene transcription (1, 3). JAK2 is activated after binding to the following Interleukin receptors: specifically IL-3 and IL-23 (4). It also plays a role in leptin signaling and control of body weight (4). A chromosomal aberration involving JAK2 is found in a form of pre-B acute myeloid leukemia (5).|
|Protein KinaseDruggable Genome Chemokine signaling pathwayJak-STAT signaling pathwayAdipocytokine signaling pathway|
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Western blot - JAK2 antibody [EPR108(2)]; All lanes : Anti-JAK2 antibody [EPR108(2)] at 1/1000 dilution.Lane 1 : TF-1 cell lysate.Lane 2 : K562 cell lysate.Lane 3 : THP-1 cell lysate.Lane 4 : Jurkat cell lysate.Lane 5 : NIH3T3 cell lysate.Lane 6 : IM-9 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 131 kDa.Observed band size : 130 kDa .