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Anti-JAK2 Antibody EPR108(2)


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SKU Description Amount Price Availability*  
TA307261 Rabbit monoclonal antibody against JAK2(clone EPR108(2)) 100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus in human JAK2 was used as an immunogen.
Clone NameEPR108(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:100 - 1:500
Predicted MW Explanation 131 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens Janus kinase 2 (JAK2)
Alternative NameJTK10; THCYT3
Database LinkNP_004963
Entrez Gene 3717 Human
Entrez Gene 16452 Mouse
Entrez Gene 24514 Rat
FunctionJAK2 is a member of the Janus family (JAK) tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction (1). The JAK family is constitutively associated with cytokine receptors; upon ligand binding, JAK phosphorylates the receptor. JAK also phosphorylates the cytokine receptor on tyrosine (Tyr) residues that serve as docking sites for cytoplasmic signal transducers and activators of transcription (STAT) proteins (2). Activated STATs translocate to the nucleus to mediate gene transcription (1, 3). JAK2 is activated after binding to the following Interleukin receptors: specifically IL-3 and IL-23 (4). It also plays a role in leptin signaling and control of body weight (4). A chromosomal aberration involving JAK2 is found in a form of pre-B acute myeloid leukemia (5).
Related PathwayProtein KinaseDruggable Genome Chemokine signaling pathwayJak-STAT signaling pathwayAdipocytokine signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - JAK2 antibody [EPR108(2)]; All lanes : Anti-JAK2 antibody [EPR108(2)] at 1/1000 dilution.Lane 1 : TF-1 cell lysate.Lane 2 : K562 cell lysate.Lane 3 : THP-1 cell lysate.Lane 4 : Jurkat cell lysate.Lane 5 : NIH3T3 cell lysate.Lane 6 : IM-9 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 131 kDa.Observed band size : 130 kDa .


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