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Also for Il1rl1 (NM_003856)
|ST2 antibody was raised against a synthetic peptide corresponding to 16 amino acids at the amino-terminus of mouse ST2. This peptide is common to all three known ST2 isoforms.|
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens interleukin 1 receptor-like 1 (IL1RL1), transcript variant 2|
|DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1|
|ST2 is a member of a superfamily containing the interleukin-1 receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF (3). More recently, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor (TLR) 4 signaling and to maintain endotoxin tolerance (4,5). It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP (6).|
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Western blot analysis of ST2 in mouse kidney lysate with ST2 antibody at 1 ug/ml in the presence (lane A) or absence (lane B) of 1 ug blocking peptide.
Immunohistochemistry of ST2 in mouse kidney tissue with ST2 antibody at 2 ug/ml.