ITPA hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. It is a member of the HAM1 NTPase protein family, and it is found in the cytoplasm and acts as a homodimer. Defects in ITPA can result in inosine triphosphate pyrophosphorylase deficiency (1).
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